androstenediol (3beta,17beta) monosulfate (2) to 1-palmitoyl-gpe (16:0)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 1-palmitoyl-gpe (16:0)
Metabolite Accession: GCST90199792
Name: 1-palmitoyl-gpe (16:0)
Hmdb Id: HMDB0011503
Super Pathway: NA
Sub Pathway: NA
Inchikey: YVYMBNSKXOXSKW

Associated Genomic Regions

Region: rs12318075

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.232
Position:
21361587
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
-8.339
Reference Allele:
T
-log10(P):
-37.131
MAF:
0.165
Beta (Num):
-0.109
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.122
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The OATP1B1 transporter, encoded by *SLCO1B1*, facilitates the hepatic uptake of conjugated steroids like androstenediol monosulfate, while its relation to lysophospholipid transport is less direct.7[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced *SLCO1B1* function can impair the hepatic uptake of various substrates, including bilirubin and urate, leading to hyperbilirubinemia (affecting MCH, MCV, TBil) and potentially contributing to gout.8[1], 9[2], 10[3] Altered lipid metabolism may also affect triglyceride levels.11[4], 12[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data