androstenediol (3beta,17beta) monosulfate (2) to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs4149026

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.127
Position:
21315415
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
8.220
Reference Allele:
A
-log10(P):
-36.134
MAF:
0.315
Beta (Num):
0.041
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
54
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 LST3 SLCO1B3

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.328
Position:
21331549
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-16.767
Reference Allele:
T
-log10(P):
-143.620
MAF:
0.155
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.214
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.428
Position:
99075038
SE (Ratio):
0.039
Effect Allele:
C
Z-score (Ratio):
-10.946
Reference Allele:
T
-log10(P):
-62.534
MAF:
0.034
Beta (Num):
-0.347
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
0.081
SE (Den):
0.040
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism

Denominator Metabolite Explanation:

Steroidogenesis

Ratio Explanation:

The ratio of androstenediol monosulfate to 21-hydroxypregnenolone disulfate may reflect the activity of the SLCO1B1 transporter, which is involved in clearing sulfated steroids.3[1], 6[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the SLCO1B1 transporter, indicated by the altered steroid ratio, is associated with hyperuricemia and gout, and also impacts statin metabolism, which is linked to coronary atherosclerosis.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data