androstenediol (3beta,17beta) monosulfate (2) to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs4149083

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.318
Position:
21380630
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-19.750
Reference Allele:
A
-log10(P):
-198.247
MAF:
0.165
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.205
SE (Den):
0.018
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 SLCO1A2 RP11-125O5.2 IAPP SLCO1B7

Region: rs118168183

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.436
Position:
99291144
SE (Ratio):
0.038
Effect Allele:
A
Z-score (Ratio):
-11.420
Reference Allele:
G
-log10(P):
-67.880
MAF:
0.026
Beta (Num):
-0.376
Novel Locus:
No
SE (Num):
0.047
Beta (Den):
0.060
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
CYP3A7 CYP3A5 ZSCAN25 CYP3A4 GS1-259H13.10

LLM Analysis

Numerator Metabolite Explanation:

Androgen and steroid hormone biosynthesis.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Androgen and steroid hormone sulfation.11[1], 12[2], 13[3], 8[4]

Ratio Explanation:

The ratio may reflect altered SLCO1B1-mediated hepatic uptake of androstenediol monosulfate for further sulfation or clearance, with decreased function leading to higher monosulfate levels.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the transport of various compounds, including bilirubin and urate, which are linked to the observed phenotypes of hyperbilirubinemia and gout.14[1], 15[2], 16[3], 17[4] This suggests a systemic effect of the transporter on multiple metabolic pathways.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data