androstenediol (3beta,17beta) monosulfate (2) to 5alpha-pregnan-3beta,20beta-diol monosulfate (1)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Metabolite Accession: GCST90199853
Name: 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Hmdb Id: HMDB0240580
Super Pathway: NA
Sub Pathway: NA
Inchikey: NOGKXXMAHGCQBS

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.277
Position:
21331549
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
-11.238
Reference Allele:
T
-log10(P):
-65.796
MAF:
0.155
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.4[1]

Denominator Metabolite Explanation:

Steroidogenesis, Progestin Metabolism.5[1], 6[2]

Ratio Explanation:

The ratio of androstenediol to pregnanediol sulfates likely reflects the substrate preference of the SLCO1B1 transporter, which is responsible for their hepatic uptake.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLCO1B1 function affects the transport of steroid sulfates and other compounds like bilirubin and uric acid, potentially contributing to cardiac arrhythmias and atherosclerosis.1[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data