androstenediol (3beta,17beta) monosulfate (2) to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.223
Position:
21331549
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-10.515
Reference Allele:
T
-log10(P):
-57.873
MAF:
0.155
Beta (Num):
-0.113
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.110
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.9[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the balance between two sulfated androgen metabolites. *SLCO1B1* does not catalyze their interconversion but may transport them, influencing their circulating levels.4[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the *SLCO1B1* transporter likely impairs hepatic uptake of uric acid and bilirubin, leading to gout and hyperbilirubinemia.5[1], 11[2], 12[3] The association with atherosclerosis may be linked to altered lipid metabolism or pleiotropic effects of the gene.13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data