androstenediol (3beta,17beta) monosulfate (2) to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
-0.295
Position:
21343833
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-14.477
Reference Allele:
A
-log10(P):
-107.697
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.177
SE (Den):
0.018
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.6[1]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects altered transport activity by SLCO1B1, which handles various steroid sulfates. A variant can modify the balance of these circulating steroid hormones.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function due to a missense variant alters the transport of steroid hormones and other endogenous molecules like bilirubin and uric acid.4[1], 8[2], 9[3] This systemic change, including altered lipid metabolism, contributes to an increased risk for coronary atherosclerosis.10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data