androstenediol (3beta,17beta) monosulfate (2) to pregnenediol sulfate (c21h34o5s)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of pregnenediol sulfate (c21h34o5s)*
Metabolite Accession: GCST90199861
Name: pregnenediol sulfate (c21h34o5s)*
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs67981690

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.196
Position:
21343886
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-8.789
Reference Allele:
A
-log10(P):
-41.037
MAF:
0.131
Beta (Num):
-0.120
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
0.076
SE (Den):
0.019
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.4[1]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects the relative hepatic clearance of two steroid sulfates via the OATP1B1 transporter, for which both metabolites are substrates.3[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLCO1B1 alters OATP1B1 transporter function, impacting the hepatic clearance of its substrates, including bilirubin and steroid hormones.1[1], 7[2], 8[3] This explains the correlation between the metabolite ratio and circulating total bilirubin levels.7[4], 9[5], 8[6]

Phenotype Driver:

Gene-centric:[SLCO1B1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data