androstenediol (3beta,17beta) monosulfate (2) to androstenediol (3beta,17beta) monosulfate (1)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.227
Position:
21343833
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-14.972
Reference Allele:
A
-log10(P):
-115.022
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.110
SE (Den):
0.019
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.5[1]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.5[1]

Ratio Explanation:

The ratio of these two androstenediol monosulfate isomers likely reflects altered hepatic clearance mediated by the SLCO1B1 transporter, which is known to handle steroid sulfates.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function, indicated by the missense variant, alters transport of steroid hormones and other molecules like bilirubin and triglycerides, contributing to coronary atherosclerosis risk and the other observed metabolic phenotypes.3[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data