androstenediol (3beta,17beta) monosulfate (2) to n-oleoyltaurine

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.268
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
-9.393
Reference Allele:
A
-log10(P):
-46.590
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.151
SE (Den):
0.022
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Androgen and Estrogen Metabolism.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Fatty acid and taurine metabolism.12[1], 13[2], 14[3]

Ratio Explanation:

The ratio may reflect altered hepatic clearance by the OATP1B1 transporter, as SLCO1B1 transports conjugated steroids like the numerator and is involved in lipid metabolism.15[1], 16[2], 17[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the clearance of its many substrates, including bilirubin and lipids.15[1], 18[2] This broad metabolic disruption, reflected in the PheWAS traits (TBil, TG), is linked to coronary atherosclerosis, a phenotype associated with SLCO1B1 variants.19[3], 20[4], 21[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data