androstenediol (3beta,17beta) monosulfate (2) to n-palmitoylglycine

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs67981690

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.254
Position:
21343886
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-8.598
Reference Allele:
A
-log10(P):
-39.357
MAF:
0.131
Beta (Num):
-0.120
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
0.134
SE (Den):
0.022
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis; Androgen Metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty Acid Amide Biosynthesis.6[1], 7[2]

Ratio Explanation:

This ratio reflects SLCO1B1 activity; decreased function likely increases plasma levels of the transported steroid sulfate relative to the non-transported n-palmitoylglycine.2[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function reduces hepatic clearance of its substrates, including urate and bilirubin, leading to gout and hyperbilirubinemia (elevated TBil, MCH, MCV).1[1], 10[2], 11[3], 12[4], 13[5] The ratio reflects this reduced transporter activity which is also linked to the phenotypes.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data