androstenediol (3beta,17beta) monosulfate (2) to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.254
Position:
21343833
SE (Ratio):
0.028
Effect Allele:
C
Z-score (Ratio):
-9.018
Reference Allele:
A
-log10(P):
-43.098
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.136
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis, Androgen and estrogen metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (acylcarnitine).6[1], 7[2]

Ratio Explanation:

A decreased function of the SLCO1B1 transporter could alter the hepatic uptake of androstenediol monosulfate and affect fatty acid metabolism, influencing this ratio.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can lead to higher circulating levels of its substrates and has been associated with coronary atherosclerosis and altered levels of triglycerides, total bilirubin, and other markers, likely through its broad role in hepatic clearance.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data