androstenediol (3beta,17beta) monosulfate (2) to dihomo-linoleoylcarnitine (c20:2)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90200144
Name: dihomo-linoleoylcarnitine (c20:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.258
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
-8.937
Reference Allele:
A
-log10(P):
-42.361
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.140
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis6[1], 7[2]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Carnitine)8[1], 9[2]

Ratio Explanation:

The ratio likely reflects altered hepatic uptake by the SLCO1B1 transporter, which can transport steroid sulfates but its interaction with acylcarnitines is less defined.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the clearance of its substrates, including bilirubin and steroid hormones.3[1], 10[2] This connects to the observed phenotypes of altered bilirubin, MCH, MCV11[3], 12[4], and the reported association with coronary atherosclerosis.13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data