androstenediol (3beta,17beta) monosulfate (2) to 3-formylindole

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Associated Genomic Regions

Region: rs1185976

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.196
Position:
25822363
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-8.440
Reference Allele:
C
-log10(P):
-37.988
MAF:
0.291
Beta (Num):
-0.101
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 SLC17A2 HIST1H2BA

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis and sulfation.11[1], 12[2], 13[3]

Denominator Metabolite Explanation:

Tryptophan metabolism.14[1], 15[2]

Ratio Explanation:

The ratio of a sulfated steroid to a tryptophan metabolite may reflect the transport activity of SLC17 proteins which can handle diverse organic anions.16[1], 17[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A gene family, particularly SLC17A1 and SLC17A3, function as uric acid transporters.7[1], 2[2], 9[3], 18[4], 4[5], 19[6], 5[7], 20[8] Altered function of these transporters likely influences both uric acid levels and the balance of other transported organic anions, such as steroid sulfates, potentially impacting hematological traits.21[9], 22[10], 23[11]

Phenotype Driver:

Gene-centric:SLC17A1/SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data