androstenediol (3beta,17beta) monosulfate (2) to androsterone sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs2900478

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.206
Position:
21368797
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-10.064
Reference Allele:
T
-log10(P):
-53.189
MAF:
0.165
Beta (Num):
-0.113
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.093
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 4[2]

Ratio Explanation:

The ratio reflects altered hepatic uptake of sulfated steroids, as SLCO1B1 transports both metabolites, and genetic variants can decrease its transport efficiency.6[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SLCO1B1 variants decrease the hepatic uptake of many compounds, including uric acid and steroid sulfates. This impaired clearance directly contributes to hyperuricemia and gout, with the altered steroid ratio being a parallel consequence of the same transporter defect.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data