androstenediol (3beta,17beta) monosulfate (2) to bilirubin (e,e)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of bilirubin (e,e)*
Metabolite Accession: GCST90200686
Name: bilirubin (e,e)*
Hmdb Id: HMDB0240584
Super Pathway: NA
Sub Pathway: NA
Inchikey: BPYKTIZUTYGOLE

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.250
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
-8.611
Reference Allele:
A
-log10(P):
-39.468
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.133
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Steroid sulfation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Denominator Pathway(s): Heme degradation pathway.9[1], 10[2], 11[3]

Ratio Explanation:

Ratio Interpretation: Reduced SLCO1B1 function can decrease hepatic uptake of both androstenediol sulfate and bilirubin, potentially altering their circulating ratio, although the direct relationship is complex.3[1], 12[2]

Ratio Evidence:

Ratio Evidence Level: metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: Reduced SLCO1B1 function alters bilirubin and steroid hormone levels, which is associated with changes in blood lipid profiles (triglycerides) and hematological indices (MCH, MCV), and may contribute to coronary atherosclerosis risk.13[1], 14[2], 15[3], 16[4]

Phenotype Driver:

Primary Driver Of Phenotype Link: Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data