androstenediol (3beta,17beta) monosulfate (2) to bilirubin degradation product, c17h18n2o4 (3)**

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90200703
Name: bilirubin degradation product, c17h18n2o4 (3)**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs67981690

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.245
Position:
21343886
SE (Ratio):
0.031
Effect Allele:
G
Z-score (Ratio):
-8.000
Reference Allele:
A
-log10(P):
-34.323
MAF:
0.131
Beta (Num):
-0.120
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
0.125
SE (Den):
0.022
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Androgen/Estrogen Metabolism.5[1]

Denominator Metabolite Explanation:

Heme degradation, Bilirubin metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the relative hepatic uptake efficiency of a sulfated androgen and bilirubin, both of which are transported by the SLCO1B1 protein.9[1], 3[2], 4[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can impair hepatic uptake of both steroid sulfates and bilirubin, altering their ratio.2[1], 10[2], 4[3] This dysfunction is linked to elevated total bilirubin and is also associated with an increased risk of gout.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data