androstenediol (3beta,17beta) monosulfate (2) to bilirubin (z,z)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of bilirubin (z,z)
Metabolite Accession: GCST90200704
Name: bilirubin (z,z)
Hmdb Id: HMDB0000054
Super Pathway: NA
Sub Pathway: NA
Inchikey: BPYKTIZUTYGOLE

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.265
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
-9.276
Reference Allele:
A
-log10(P):
-45.484
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.147
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis and sulfation.

Denominator Metabolite Explanation:

Heme catabolism.5[1], 6[2], 7[3], 8[4]

Ratio Explanation:

This ratio reflects the transport activity of OATP1B1, where altered function can affect the relative plasma levels of both androstenediol monosulfate and bilirubin.1[1], 2[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced OATP1B1 function, indicated by the metabolic ratio, is linked to coronary atherosclerosis and altered blood parameters (MCH, MCV, total bilirubin), likely through its broad effects on clearing endogenous compounds and drugs, including statins.10[1], 11[2], 12[3], 13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data