androstenediol (3beta,17beta) monosulfate (1) to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs72838129

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.188
Position:
101604481
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
7.640
Reference Allele:
T
-log10(P):
-31.457
MAF:
0.059
Beta (Num):
0.052
Novel Locus:
Yes ✔️
SE (Num):
0.029
Beta (Den):
-0.136
SE (Den):
0.029
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.397
Position:
99075038
SE (Ratio):
0.032
Effect Allele:
C
Z-score (Ratio):
-12.523
Reference Allele:
T
-log10(P):
-81.173
MAF:
0.034
Beta (Num):
-0.382
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.015
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism

Denominator Metabolite Explanation:

Androgen and estrogen metabolism

Ratio Explanation:

The ratio reflects the relative activity of sulfation and desulfation or transport of androstenediol sulfates, with ABCC2 potentially mediating their cellular efflux.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered ABCC2 function likely affects the transport and levels of steroid sulfates, which could influence inflammatory pathways (CRP, WBC) and liver function (AST, ALT, GGT).

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data