androstenediol (3beta,17beta) monosulfate (1) to pregnenolone sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of pregnenolone sulfate
Metabolite Accession: GCST90199873
Name: pregnenolone sulfate
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs11191421

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.136
Position:
104623053
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-8.304
Reference Allele:
C
-log10(P):
-36.834
MAF:
0.244
Beta (Num):
-0.073
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.063
SE (Den):
0.017
No CNV overlap
rQTL cluster:
66
Reaction Distance:
NA
Closest Genes:
C10orf32-ASMT C10orf32 AS3MT CYP17A1 WBP1L

LLM Analysis

Numerator Metabolite Explanation:

Androgen/estrogen biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Steroidogenesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the conversion of the upstream steroid precursor, pregnenolone sulfate, to the downstream androgen precursor, androstenediol sulfate, a process mediated by CYP17A1.3[1], 10[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in androgen synthesis, influenced by CYP17A1 activity and marked by the androstenediol/pregnenolone sulfate ratio, are associated with changes in hematological traits like white blood cell and neutrophil counts, as androgens are known to modulate hematopoiesis.12[1], 13[2], 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:CYP17A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data