pregnenolone sulfate to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of pregnenolone sulfate
Metabolite Accession: GCST90199873
Name: pregnenolone sulfate
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs11211406

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.161
Position:
47413786
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
11.178
Reference Allele:
A
-log10(P):
-65.119
MAF:
0.208
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.152
SE (Den):
0.018
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

Region: rs1165209

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.156
Position:
25801319
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-13.601
Reference Allele:
A
-log10(P):
-95.333
MAF:
0.444
Beta (Num):
0.005
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.161
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis7[1], 8[2]

Denominator Metabolite Explanation:

Steroid metabolism, Steroid sulfation9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio of pregnenolone sulfate to its downstream metabolite 21-hydroxypregnenolone disulfate may reflect steroid metabolic activity, potentially influenced by shared transport mechanisms.13[1], 14[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely affects urate transport, leading to changes in serum uric acid levels.4[1], 13[2], 15[3] The association with hematological traits might stem from the pleiotropic effects of steroids on blood cell production or a yet-unknown role of SLC17A4 in blood cell function.16[4], 17[5], 18[6]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data