sphingomyelin (d18:1/18:1, d18:2/18:0) to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of sphingomyelin (d18:1/18:1, d18:2/18:0)
Metabolite Accession: GCST90199878
Name: sphingomyelin (d18:1/18:1, d18:2/18:0)
Hmdb Id: HMDB0012101
Super Pathway: NA
Sub Pathway: NA
Inchikey: NBEADXWAAWCCDG

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.243
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-10.628
Reference Allele:
A
-log10(P):
-59.071
MAF:
0.344
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.131
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

GPI anchor biosynthesis, Glycerophospholipid metabolism.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects FADS1/FADS2 activity, which influences the types of fatty acids incorporated into sphingomyelins versus GPI-anchored lipids, affecting cell membrane composition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid levels, impacting the sphingomyelin to GPI-anchor lipid ratio. This dysregulation of lipid metabolism and inflammatory precursors contributes to risks for hypercholesterolemia, cholelithiasis, asthma, and inflammatory bowel disease.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data