ergothioneine to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of ergothioneine
Metabolite Accession: GCST90199879
Name: ergothioneine
Hmdb Id: HMDB0003045
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSISHJJTAXXQAX

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs12210538

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.382
Position:
110760008
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
14.819
Reference Allele:
A
-log10(P):
-112.725
MAF:
0.240
Beta (Num):
0.199
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.183
SE (Den):
0.017
No CNV overlap
rQTL cluster:
103
Reaction Distance:
NA
Closest Genes:
SLC22A16 DDO METTL24 CDK19 CDC40

LLM Analysis

Numerator Metabolite Explanation:

Histidine/thiol metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/carnitine shuttle7[1]

Ratio Explanation:

The ratio may reflect the balance between cellular uptake of ergothioneine, an antioxidant, and carnitine, essential for fatty acid oxidation, mediated by SLC22A transporters.1[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4/A5 affect the transport of ergothioneine (antioxidant) and carnitine (fatty acid metabolism), influencing the balance of inflammation and oxidative stress, which are linked to phenotypes like skin cancer, asthma, and inflammatory skin disorders.8[1], 4[2], 9[3], 10[4], 1[5]

Phenotype Driver:

Gene-centric:SLC22A4/SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data