cis-4-decenoylcarnitine (c10:1) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs12562586

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.169
Position:
151898947
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
11.668
Reference Allele:
G
-log10(P):
-70.760
MAF:
0.375
Beta (Num):
0.044
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.125
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine metabolism.2[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.

Ratio Explanation:

Decreased ACADM activity leads to the accumulation of its substrate, cis-4-decenoylcarnitine, and the shunting of fatty acids to alternative pathways like omega-oxidation, altering tetradecadienoate levels.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data