(16 or 17)-methylstearate (a19:0 or i19:0) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.194
Position:
61591636
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
9.920
Reference Allele:
C
-log10(P):
-51.738
MAF:
0.131
Beta (Num):
0.034
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Branched-chain fatty acid synthesis

Denominator Metabolite Explanation:

Polyunsaturated omega-6 fatty acid synthesis

Ratio Explanation:

An elevated ratio suggests decreased FADS2 activity, leading to lower production of docosapentaenoate (DPA), a long-chain PUFA, relative to methylstearate, a branched-chain fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS2 variants are associated with altered PUFA metabolism, which influences risk for type 2 diabetes, skin cancer, and abnormal cardiometabolic profiles (e.g., lipids, glucose).2[1], 3[2], 4[3] The ratio reflects this genetic-metabolic link to disease phenotypes.

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data