(16 or 17)-methylstearate (a19:0 or i19:0) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.135
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
8.500
Reference Allele:
C
-log10(P):
-38.504
MAF:
0.296
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism.8[1], 9[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects altered fatty acid metabolism, where decreased CYP4F2 function may lead to reduced omega-oxidation of fatty acids, impacting hexadecanedioate production.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 variant reduces enzyme activity, altering fatty acid metabolism.1[1], 13[2] This shift is linked to coronary atherosclerosis and ischemic heart disease, potentially through pro-inflammatory mechanisms or altered levels of signaling molecules like 20-HETE.14[3], 15[4], 16[5] Elevated hexadecanedioate is also independently associated with increased blood pressure.10[6], 17[7]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data