(16 or 17)-methylstearate (a19:0 or i19:0) to stearate (18:0)

Numerator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.098
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-8.172
Reference Allele:
G
-log10(P):
-35.729
MAF:
0.176
Beta (Num):
-0.001
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Biosynthesis, Branched-Chain Fatty Acid Metabolism4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty Acid Biosynthesis, Mitochondrial Beta-Oxidation8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio reflects SCD activity, which desaturates stearate. Elevated SCD is associated with increased cardiovascular risk factors and related diseases.12[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Elevated SCD activity, which desaturates stearate into oleate, is linked to hyperlipidemia and atherosclerosis. The ratio of these fatty acids is a marker for these conditions and is associated with coronary artery disease, myocardial infarction, and cholelithiasis.1[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data