cis-4-decenoate (10:1n6)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.448
Position:
151879761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-26.767
Reference Allele:
G
-log10(P):
-361.750
MAF:
0.316
Beta (Num):
-0.409
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.039
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation and carnitine shuttle.5[1], 6[2]

Ratio Explanation:

The ratio of cis-4-decenoate to oleoylcarnitine may reflect THEM4 activity, which can hydrolyze precursors to both metabolites, thus regulating their relative abundance.7[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype association was provided, so a link between the THEM4-regulated cis-4-decenoate to oleoylcarnitine ratio and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data