cis-4-decenoate (10:1n6)* to palmitoleate (16:1n7)

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.419
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-27.653
Reference Allele:
G
-log10(P):
-385.892
MAF:
0.316
Beta (Num):
-0.409
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation

Ratio Explanation:

An increased ratio may reflect reduced ACADM activity, causing accumulation of its substrate-related metabolite cis-4-decenoate relative to palmitoleate, which is not an ACADM substrate.4[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM likely alter its enzymatic activity, changing the cis-4-decenoate to palmitoleate ratio; however, no specific phenotype has been associated in the provided data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data