4-oxo-retinoic acid to p-cresol glucuronide*

Numerator Metabolite

Metabolite Accession: GCST90199894
Name: 4-oxo-retinoic acid
Hmdb Id: HMDB0006285
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of p-cresol glucuronide*
Metabolite Accession: GCST90200003
Name: p-cresol glucuronide*
Hmdb Id: HMDB0011686
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPAUCQAJHLSMQW

Associated Genomic Regions

Region: rs11893247

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.415
Position:
234565254
SE (Ratio):
0.039
Effect Allele:
G
Z-score (Ratio):
-10.543
Reference Allele:
T
-log10(P):
-58.169
MAF:
0.083
Beta (Num):
-0.211
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
0.204
SE (Den):
0.027
No CNV overlap
rQTL cluster:
137
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A8 UGT1A9 UGT1A7 UGT1A6

LLM Analysis

Numerator Metabolite Explanation:

Retinoid metabolism.8[1], 9[2], 10[3], 11[4], 12[5]

Denominator Metabolite Explanation:

Tyrosine metabolism, Glucuronidation.13[1], 14[2]

Ratio Explanation:

The ratio reflects the relative glucuronidation activity of UGT1A enzymes on 4-oxo-retinoic acid and p-cresol, potentially influenced by substrate competition.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Variation in UGT1A genes, particularly UGT1A1, alters the efficiency of bilirubin glucuronidation, directly impacting total bilirubin levels.3[1], 4[2], 15[3], 16[4], 17[5] The link to total cholesterol is less direct but may be mediated by ATG16L1's role in cholesterol homeostasis or broader metabolic regulation by UGT enzymes.18[6], 19[7], 20[8], 21[9], 22[10]

Phenotype Driver:

Gene-centric:UGT1A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data