1-lignoceroyl-gpc (24:0) to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.406
Position:
61570783
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-22.128
Reference Allele:
T
-log10(P):
-248.145
MAF:
0.340
Beta (Num):
-0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism, Fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Lysophospholipid metabolism, Phosphatidylethanolamine biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between a very-long-chain saturated fatty acid and a polyunsaturated fatty acid, potentially influenced by FADS desaturase activity.7[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by eQTLs, alters the balance of fatty acid types. This dysregulation is linked to changes in lipid profiles and inflammatory responses, contributing to phenotypes like hypercholesterolemia, type 2 diabetes, and cholelithiasis.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data