1-lignoceroyl-gpc (24:0) to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.204
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-10.546
Reference Allele:
T
-log10(P):
-58.195
MAF:
0.347
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.075
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism6[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylethanolamine biosynthesis7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio of a very long-chain saturated lysophosphatidylcholine to a monounsaturated lysophosphatidylethanolamine may reflect altered fatty acid desaturase activity, impacting membrane composition and lipid signaling.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, alters long-chain polyunsaturated fatty acid synthesis.3[1], 11[2] This dysregulation of lipid metabolism is linked to an increased risk for cholelithiasis, hypercholesterolemia, and other inflammatory conditions.12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data