1-lignoceroyl-gpc (24:0) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.454
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-22.246
Reference Allele:
T
-log10(P):
-250.761
MAF:
0.347
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.324
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Very-long-chain fatty acid metabolism

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis

Ratio Explanation:

The ratio compares a saturated lysophosphatidylcholine to a phosphatidylcholine containing a FADS1 substrate (dihomo-linolenoyl-gpc), likely reflecting FADS1 enzyme activity and overall lipid balance.4[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by the ratio, alters the balance of pro- and anti-inflammatory lipid mediators derived from polyunsaturated fatty acids, plausibly contributing to inflammatory conditions like asthma and metabolic phenotypes including hypercholesterolaemia and altered lipoprotein levels.5[1], 4[2], 6[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data