1-lignoceroyl-gpc (24:0) to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.356
Position:
61557803
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-16.241
Reference Allele:
T
-log10(P):
-134.908
MAF:
0.347
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysolipid metabolism6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between a very-long-chain saturated fatty acid and a polyunsaturated fatty acid, potentially indicating altered fatty acid desaturase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are known to alter PUFA metabolism, which could influence the levels of both lignoceroyl-gpc and dilinoleoyl-gpe.3[1], 4[2], 12[3], 13[4] This altered lipid metabolism is associated with various phenotypes including cholelithiasis, hypercholesterolemia, and inflammatory conditions like asthma and IBD, all of which have links to lipid signaling and inflammation.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data