1-lignoceroyl-gpc (24:0) to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.297
Position:
61551927
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-13.838
Reference Allele:
A
-log10(P):
-98.600
MAF:
0.342
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.169
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Very-long-chain fatty acid elongation.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Linoleic acid metabolism, PUFA biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect the balance between very-long-chain saturated lipids and PUFA-containing plasmalogens, which is likely influenced by FADS1 enzymatic activity.1[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters desaturase efficiency, impacting the balance of pro-inflammatory saturated and anti-inflammatory polyunsaturated fatty acids.10[1], 11[2], 12[3] This dysregulation of lipid metabolism and inflammatory precursors contributes to phenotypes like cholelithiasis, dyslipidemia, and asthma.11[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:[FADS1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data