1-lignoceroyl-gpc (24:0) to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.257
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-14.000
Reference Allele:
T
-log10(P):
-100.868
MAF:
0.347
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Inositol phosphate metabolism, Glycerophospholipid metabolism.5[1]

Ratio Explanation:

The ratio reflects the balance between very-long-chain saturated fatty acids and monounsaturated fatty acids in complex lipids, influenced by FADS desaturase activity.6[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, affecting the balance of fatty acid species.3[1] This dysregulation of lipid profiles contributes to phenotypes like dyslipidemia, type 2 diabetes, and inflammatory conditions such as IBD and asthma.2[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data