1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-oleoyl-gpc (18:1)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-oleoyl-gpc (18:1)
Metabolite Accession: GCST90199727
Name: 1-oleoyl-gpc (18:1)
Hmdb Id: HMDB0002815
Super Pathway: NA
Sub Pathway: NA
Inchikey: YAMUFBLWGFFICM

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.172
Position:
61569830
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
-13.443
Reference Allele:
C
-log10(P):
-93.188
MAF:
0.339
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between plasmalogen and lysophosphatidylcholine species, potentially influenced by FADS activity on fatty acid precursors for their synthesis.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, influencing the composition of lipids like plasmalogens and lysophosphatidylcholines. This dysregulated lipid metabolism is associated with an increased risk for inflammatory conditions such as inflammatory bowel disease and metabolic disorders like type 2 diabetes.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data