1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs12878807

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.102
Position:
67964688
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-8.749
Reference Allele:
T
-log10(P):
-40.679
MAF:
0.476
Beta (Num):
-0.096
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.006
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 EIF2S1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.8[1]

Ratio Explanation:

The ratio may reflect TMEM229B's role in regulating plasmalogen levels, where higher TMEM229B activity could decrease the numerator relative to the denominator.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; however, TMEM229B's influence on plasmalogen levels could be a mediating factor in inflammatory or neurodegenerative diseases where plasmalogens are implicated.1[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:TMEM229B

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data