1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs11158671

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.113
Position:
67965452
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-9.262
Reference Allele:
G
-log10(P):
-45.355
MAF:
0.476
Beta (Num):
-0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.018
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 EIF2S1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Ether lipid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio reflects the balance between plasmalogens and their breakdown or precursor lysophospholipids, potentially indicating altered ether lipid metabolism regulated by TMEM229B.1[1], 3[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data is available to establish a link.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data