1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.290
Position:
61569830
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-19.398
Reference Allele:
C
-log10(P):
-191.341
MAF:
0.339
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, Ether lipid metabolism6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism9[1]

Ratio Explanation:

The ratio reflects the balance between plasmalogen and lysophosphatidylcholine species, which is influenced by FADS desaturase activity on fatty acid precursors.1[1], 10[2], 11[3], 12[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter the balance of polyunsaturated fatty acids, affecting circulating lipid levels.5[1], 13[2] This dyslipidemia, particularly altered cholesterol, is a known risk factor for the development of pure hypercholesterolemia and cholelithiasis.14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data