1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.444
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-24.476
Reference Allele:
A
-log10(P):
-302.963
MAF:
0.343
Beta (Num):
-0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS-mediated desaturation. Lower FADS activity increases the precursor linoleic acid (18:2) in the denominator relative to other complex lipids.1[1], 2[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 expression changes the ratio by affecting polyunsaturated fatty acid (PUFA) metabolism. This dysregulates inflammatory pathways and lipid profiles, contributing to phenotypes like pure hypercholesterolemia, inflammatory bowel disease, and cardiovascular diseases through effects on lipid mediators and membrane composition.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data