1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-(1-enyl-palmitoyl)-gpe (p-16:0)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Metabolite Accession: GCST90199906
Name: 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Hmdb Id: HMDB0011152
Super Pathway: NA
Sub Pathway: NA
Inchikey: QYTPGOPLNFESQC

Associated Genomic Regions

Region: rs1885041

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.106
Position:
67976325
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
-8.504
Reference Allele:
C
-log10(P):
-38.541
MAF:
0.475
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 ARG2

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Ether lipid metabolism.9[1], 7[2], 10[3], 11[4]

Ratio Explanation:

Ratio of choline to ethanolamine plasmalogens reflects headgroup synthesis balance; the role of associated gene TMEM229B in this process is unknown.6[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided; therefore, a causal link between the TMEM229B-associated plasmalogen ratio and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data