1-(1-enyl-palmitoyl)-gpc (p-16:0)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Metabolite Accession: GCST90200013
Name: sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.242
Position:
61592362
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-12.541
Reference Allele:
A
-log10(P):
-81.404
MAF:
0.344
Beta (Num):
-0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.079
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between plasmalogen and sphingomyelin pools, which can be influenced by FADS desaturase activity on fatty acid precursors.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 affect the levels of polyunsaturated fatty acids, influencing both plasmalogen and sphingomyelin composition.12[1], 10[2], 11[3], 4[4] This alteration in lipid metabolism is associated with an increased risk for inflammatory conditions, dyslipidemia, and cholelithiasis.1[5], 2[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2 1431-275-231-229-2166

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data