1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.493
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-22.419
Reference Allele:
A
-log10(P):
-254.637
MAF:
0.343
Beta (Num):
-0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and Phosphatidylcholine Biosynthesis.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Phosphatidylcholine Biosynthesis.9[1], 10[2]

Ratio Explanation:

The ratio reflects FADS1 activity, where lower levels suggest reduced conversion of precursors to products like arachidonic acid, impacting inflammatory and lipid pathways.3[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters the balance of pro-inflammatory and pro-resolving lipid mediators, contributing to an inflammatory state and dyslipidemia, which are associated with cholelithiasis.3[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data