1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.207
Position:
61593816
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-13.059
Reference Allele:
C
-log10(P):
-88.065
MAF:
0.338
Beta (Num):
-0.159
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.048
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Fatty acid metabolism5[1], 7[2]

Ratio Explanation:

This ratio may reflect the desaturation of fatty acids in plasmalogen synthesis, where FADS enzymes play a key role in producing polyunsaturated fatty acids.1[1], 2[2], 3[3], 7[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants influence fatty acid metabolism, potentially impacting inflammatory processes and cell membrane composition, which are linked to valvular heart disease and various neoplasms.1[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data