1-(1-enyl-palmitoyl)-gpc (p-16:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.330
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-17.152
Reference Allele:
A
-log10(P):
-150.174
MAF:
0.343
Beta (Num):
-0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.164
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis2[1], 3[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis4[1], 5[2]

Ratio Explanation:

The ratio reflects the balance of plasmalogen species, influenced by FADS desaturase activity on fatty acid precursors (16:0 vs. 18:0/18:2) for their synthesis.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster alters desaturase activity, impacting the balance of polyunsaturated fatty acids and plasmalogens.6[1], 7[2] This dysregulation is linked to inflammation and lipid metabolism changes associated with valvular heart disease8[3], 9[4], inflammatory bowel disease10[5], 11[6], 12[7], and cholelithiasis13[8], 14[9], 15[10].

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data