1-(1-enyl-palmitoyl)-gpe (p-16:0)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Metabolite Accession: GCST90199906
Name: 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Hmdb Id: HMDB0011152
Super Pathway: NA
Sub Pathway: NA
Inchikey: QYTPGOPLNFESQC

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.192
Position:
61579463
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-10.883
Reference Allele:
A
-log10(P):
-61.840
MAF:
0.338
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the balance between ether lipid and glycerophospholipid pathways, potentially influenced by FADS desaturase activity on fatty acid precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, likely shifts the balance of polyunsaturated fatty acids, affecting the composition of ether lipids and glycerophospholipids, which in turn contributes to the inflammatory and lipid metabolism-related aspects of the associated phenotypes.5[1], 6[2], 4[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data