1-(1-enyl-palmitoyl)-gpe (p-16:0)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Metabolite Accession: GCST90199906
Name: 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Hmdb Id: HMDB0011152
Super Pathway: NA
Sub Pathway: NA
Inchikey: QYTPGOPLNFESQC

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs174584

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.124
Position:
61610750
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-7.468
Reference Allele:
G
-log10(P):
-30.141
MAF:
0.353
Beta (Num):
-0.065
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.059
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, Ether lipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen remodeling, Ether lipid metabolism.6[1], 4[2]

Ratio Explanation:

The ratio signifies the acylation of 1-(1-enyl-palmitoyl)-gpe (p-16:0)* to form 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*, a process influenced by FADS-mediated fatty acid availability.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter fatty acid metabolism, which impacts the plasmalogen ratio.9[1] This dysregulation of lipid and inflammatory pathways likely contributes to the associated phenotypes of cholelithiasis, dyslipidemia, asthma, and dermatitis.10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data