1-(1-enyl-palmitoyl)-gpe (p-16:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Metabolite Accession: GCST90199906
Name: 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Hmdb Id: HMDB0011152
Super Pathway: NA
Sub Pathway: NA
Inchikey: QYTPGOPLNFESQC

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.236
Position:
61551927
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-14.029
Reference Allele:
A
-log10(P):
-101.277
MAF:
0.341
Beta (Num):
-0.068
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.169
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis

Denominator Metabolite Explanation:

Plasmalogen biosynthesis

Ratio Explanation:

This ratio reflects the acylation of the lysoplasmalogen numerator to the plasmalogen denominator, a process influenced by FADS-mediated synthesis of polyunsaturated fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, impacting lipid metabolism.3[1], 4[2] This dysregulation can affect circulating lipoproteins and inflammatory pathways, contributing to phenotypes like hypercholesterolemia and asthma, with the ratio serving as a biomarker for FADS activity.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data