1-(1-enyl-palmitoyl)-gpe (p-16:0)* to linoleoylcholine*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Metabolite Accession: GCST90199906
Name: 1-(1-enyl-palmitoyl)-gpe (p-16:0)*
Hmdb Id: HMDB0011152
Super Pathway: NA
Sub Pathway: NA
Inchikey: QYTPGOPLNFESQC

Denominator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Associated Genomic Regions

Region: rs174529

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.139
Position:
61543961
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-7.488
Reference Allele:
T
-log10(P):
-30.293
MAF:
0.366
Beta (Num):
-0.065
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism / Plasmalogen synthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism / Fatty acid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, contrasting a saturated ether lipid (plasmalogen) with a lysophospholipid containing a FADS substrate-derived linoleoyl acyl chain.2[1], 5[2], 3[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, affecting lipid profiles and inflammatory responses, which plausibly explains the link to cholelithiasis, hypercholesterolemia, phlebitis, and asthma.1[1], 8[2], 9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data