eicosanedioate (c20-dc) to n-acetyl-2-aminooctanoate*

Numerator Metabolite

Structure of eicosanedioate (c20-dc)
Metabolite Accession: GCST90199909
Name: eicosanedioate (c20-dc)
Hmdb Id: HMDB0242141
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJOJFIHJIRWASH

Denominator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.268
Position:
21343833
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
10.887
Reference Allele:
A
-log10(P):
-61.890
MAF:
0.155
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.105
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Denominator Metabolite Explanation:

Fatty acid and amino acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio likely reflects reduced hepatic uptake of eicosanedioate by SLCO1B1, as decreased function would increase its plasma concentration, altering the ratio to N-acetyl-2-aminooctanoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function, indicated by the altered ratio, affects the transport of bilirubin and lipids. This leads to phenotypes like high bilirubin, altered triglycerides, and increased coronary atherosclerosis risk.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data